Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database

Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database

Blog Article

Summary: Many experimental studies have examined behavioral and electrophysiological responses of mosquitoes to odors.However, the differences across studies in data collection, processing, and reporting make it difficult to perform large-scale analyses combining data from multiple studies.Here we extract and standardize data for 12 mosquito species, along with medline remedy phytoplex protectant z-guard paste Drosophila melanogaster for comparison, from over 170 studies and curate the Mosquito Olfactory Response Ensemble (MORE), publicly available at https://neuralsystems.github.

io/MORE.We demonstrate the ability of MORE in generating biological insights by finding patterns across studies.Our analyses reveal that ORs are tuned to specific ranges of several physicochemical properties of odorants; the empty-neuron recording technique for measuring OR responses maybelline green concealer is more sensitive than the Xenopus oocyte technique; there are systematic differences in the behavioral preferences reported by different types of assays; and odorants tend to become less attractive or more aversive at higher concentrations.